Welcome to the Cancer Genomics and Systems Biology Group!
Our group, headed by Dr. Subhajyoti De at Rutgers Cancer Institute, develop and apply genomics, systems biology, and mathematical modeling approaches to understand the biology of cancer and use that knowledge for better diagnosis, stratification, and treatment of the disease.
We are part of the Rutgers CINJ Precision Medicine Initiative and Center for Systems and Computational Biology. We closely collaborate with several research groups on different aspects of basic and clinical cancer research. Please see our Research and Publications page for more details on the recent projects.
Members of our lab have diverse background, with training in computer science, mathematics, engineering, genomics, and molecular biology. Graduate students at Rutgers are encouraged to enquire about possibility of a rotation project. We have no current opening for postdoctoral positions but informal inquiries of open positions are very welcome. Please find our address on the Contact page.
News and updates
Sep 7, 2016
Subho giving an invited talk at Japanese Society of Mathematical Biology in University of Kyushu, Japan.
June 3, 2016
Vinod's paper on somatic duon mutations, those that changes both the sequence and expression of gene products in cancer is now published.
May 16, 2016
Subho giving an invited talk at the ISCB Canadian Computational Biology Conference in Toronto.
May 2, 2016
Subho giving a lecture at the PQG seminar series at Harvard School of Public Health.
Mar 3, 2016
We are proud to receive continued patronage from the Boettcher Family for our research.
Feb 15, 2016
Vinod's paper on the landscape of somatic mutations in benign tissues is published in Nucleic Acid Research.
Feb 1, 2016
Our group moves to Rutgers Cancer institute of New Jersey.
Nov 20, 2015
Our paper SomVarIUS: Somatic variant identification from unpaired tissue samples is now published.
Oct 26, 2015
Subho gave a talk on signatures of accelerated somatic evolution in Cold Spring Harbor Genome Informatics meeting.
May 01, 2015
Kyle's paper on signatures of accelerated somatic evolution in different cancer types is now online.
Dec 29, 2014
Anna's paper is accepted in Nature. Yehh!
Dec 12, 2014
Kyle and Subho giving talks at the Rocky conference in Snowmass.
July 01, 2014
Kyle Smith joins the group as a graduate student! Welcome Kyle!
June 05, 2014
It is an honor to be a part of the Boettcher family!
June 5, 2014
Ondrej's paper is published today in PLoS Computational Biology. Looks cool!
Mar 25, 2014
Our paper on somatic mosaicism is accepted in Cell Reports. Thanks everyone for constructive comments!
Mar 12, 2014
We welcome Prof. Hiroshi Haeno as a short-term visitor in our group! Looking forward to some math modeling.
Dec 22, 2013
Rita's paper "Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes" is accepted for publication in Blood. Yeeh!
Dec 10, 2013
Mohamed Abdalla joins the group through Denver STaRS program. Welcome Mohamed!
Oct 1, 2013
Subho is invited to be a faculty member of the Department of Biostatistics and Informatics at the Colorado School of Public Health. We are looking forward to working together with statistics-gurus.
Sep 6, 2013
Brent's paper 'CruzDB: software for annotation of genomic intervals with UCSC genome-browser database' has been accepted for publication in Bioinformatics.. We are excited that the Bioinformatics community is already liking it.
July 29, 2013
We are looking forward to the summer party this Saturday!
July 25, 2013
Vinod Yadav joins the group from Institute of Genomics and Integrative Biology. Welcome Vinod!
July 1, 2013
A good start of the week! 'The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment' - is accepted for publication in Briefings in Bioinformatics. It has been a pleasure working with you, Brent and Katerina :-)
June 24, 2013
Our paper ‘Loss of heterozygosity preferentially occurs in early replicating regions in cancer genomes’ is published as a Featured Article in Nucleic Acids Research. Many thanks to our colleagues who gave us outstanding feedback on this work!
June 3, 2013
Laura Stevens joins the group from Univ. Colorado Boulder. Welcome Laura!
May 28, 2013
Our paper ‘Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients’ is published as advanced online publication in Genes Chromosomes and Cancer. It has been highlighted by MDLinx as a spotlight article.
Mar 21, 2013
The book 'Stress-Induced Mutagenesis' is out. Our Chapter-13: Revisiting Mutagenesis in the Age of High-Throughput Sequencing - is looking nice! Thanks David Mittelman!
Jan 10, 2013Finally! Our paper 'Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity' is now published in PLoS Genetics. It has been highlighted in Science Daily and C3 magazine!
Dec 7, 2012
Presenting at Rocky 2012 in Snowmass. It is a great meeting with excellent talks by colleagues from around the country.
Dec 06, 2012
'DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes' is accepted for publication in Nature Communications. well done Lin!
Nov 26, 2012
Emmanuel's paper 'Cellular crowding imposes global constraints on the chemistry and evolution of proteome' is accepted for publication in PNAS. Exciting!
Nov 11, 2012
Subho becoming a member of the Computational Biosciences Training Program and also University of Colorado Cancer Center at AMC.
Sep 1, 2012
The lab starts on the third floor of RC2 in the Anschutz Medical Campus of the University of Colorado.